GnRH & LHRH Peptides

 

 

 

 

 

 

 

 

  1. API : Triptorelin Acetate

Cas. No. :    140194 – 24 – 7

Chemical Structure :

 

Sequence :  Pyr-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2

Treatment for : Hormone-responsive cancers such as prostate or breast cancer, precocious puberty, estrogen-dependent conditions (such as endometriosis or uterine fibroids), and reproduction.

 

 

  1. API : Alarelin Acetate

Cas No. :    79561 – 22 – 1

Chemical Structure :

 

Sequence :   Pyr-His-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-NHEt.2CH3CO2H

Treatment for : Alarelin is known for its induction of ovulation and is used to treat endometriosis. Alarelin Acetate is the acetate form of a hypothalamic peptide that stimulates the release of FSH and LH from the pituitary gland.

 

 

  1. API : Fertirelin Acetate

Cas No. :    66002 – 66 – 2

Chemical Structure :

 

Sequence :   Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-NHEt

Treatment for : Various kinds of ovarian failure in cattle

 

 

  1. API : Gonadorelin

Cas No. :    33515 – 09 – 2

Chemical Structure :

 

Sequence :   Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2

Treatment for : It is used as a diagnostic agent to assess pituitary gland function. It is also used in the treatment of primary hypothalamic amenorrhea, hypogonadotropic hypogonadism (e.g., Kallmann syndrome), delayed puberty, cryptorchidism, and infertility.

 

 

  1. API : Buserelin Acetate

Cas No. :    57982 – 77 – 1

Chemical Structure :

 

Sequence :  Pyr-His-Trp-Ser-Tyr-D-Ser(tBu)-Leu-Arg-Pro-NHEt

Treatment for : Hormone-responsive cancers including prostate cancer and premenopausal breast cancer, sex hormone-dependent uterine diseases including endometrial hyperplasia, endometriosis, and uterine fibroids, and in assisted reproduction for female infertility.

 

 

  1. API : Leuprolide Acetate

Cas No. :    74381 – 53 – 6

Chemical Structure :

 

Sequence :  Pyr-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt

Treatment for : Leuprolide is used to treat advanced prostate cancer. It is also used to treat uterine fibroids and endometriosis. Leuprolide is also under investigation for possible use in the treatment of mild to moderate Alzheimer’s disease.

 

 

  1. API : Goserelin Acetate

Cas No. :    65807 – 02 – 5

Chemical Structure :

 

Sequence :   Pyr-His-Trp-Ser-Tyr-D-Ser(tBu)-Leu-Arg-Pro-NHNHCONH2.CH3CO2H

Treatment for : It is used in treatments of malignant neoplasms of the prostate, uterine fibromas, and metastatic breast cancer.

 

 

  1. LHRH ( Salmon )

Cas No. :    86073 – 88 – 3

Chemical Structure :

 

Sequence :  Pyr-His-Trp-Ser-Tyr-Gly-Trp-Leu-Pro-Gly-NH2

Treatment for : Reproductive hormone. Modulates anterior pituitary and neural function, stimulates gonadotropin release, increases testosterone levels and regulates reproductive function.

Kimia Pajouh Dorsa

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